CTH antibody (AA 1-70)

Catalog No. ABIN7148969

Product Details anti-CTH Antibody

Target: CTH (Cystathionase (Cystathionine gamma-Lyase) (CTH))

Binding Specificity: AA 1-70

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTH antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cystathionine gamma-lyase protein (1-70AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CTH

Target: CTH (Cystathionase (Cystathionine gamma-Lyase) (CTH))

Alternative Name: CTH (CTH Products)

Background:

Background: Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.

Aliases: CGL_HUMAN antibody, CTH antibody, cystathionase (cystathionine gamma-lyase) antibody, Cystathionine gamma lyase antibody, Cystathionine gamma-lyase antibody, Cysteine desulfhydrase antibody, Gamma cystathionase antibody, Gamma-cystathionase antibody, Homoserine deaminase antibody, Homoserine dehydratase antibody, MGC9471 antibody

UniProt: P32929

Pathways: ER-Nucleus Signaling, Warburg Effect