Cyclin H antibody (AA 261-319)

Catalog No. ABIN7148939

Product Details anti-Cyclin H Antibody

Target: Cyclin H (CCNH)

Binding Specificity: AA 261-319

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin H antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cyclin-H protein (261-319AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Cyclin H

Target: Cyclin H (CCNH)

Alternative Name: CCNH (CCNH Products)

Synonyms: zgc:114132 antibody, cak antibody, p34 antibody, p37 antibody, Cych antibody, ACYPI004637 antibody, ccnh antibody, Cyclin-H antibody, 142767_at antibody, CG7405 antibody, Dmel\\CG7405 antibody, CAK antibody, 6330408H09Rik antibody, AI661354 antibody, AV102684 antibody, AW538719 antibody, ccnh-A antibody, cyclin H antibody, cyclin-H antibody, Cyclin H antibody, CYclin H antibody, cyclin H L homeolog antibody, CCNH antibody, ccnh antibody, LOC5577539 antibody, Cych antibody, CycH antibody, cyh-1 antibody, Ccnh antibody, ccnh.L antibody

Background:

Background: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Aliases: 6330408H09Rik antibody, AI661354 antibody, AV102684 antibody, AW538719 antibody, CAK antibody, CAK complex subunit antibody, ccnh antibody, CCNH_HUMAN antibody, CDK activating kinase antibody, CDK activating kinase complex subunit antibody, Cyclin dependent kinase activating kinase antibody, cyclin dependent kinase activating kinase complex subunit antibody, Cyclin H antibody, Cyclin-H antibody, CyclinH antibody, MO15 associated protein antibody, MO15-associated protein antibody, p34 antibody, p36 antibody, p37 antibody

UniProt: P51946

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases, M Phase