CDK7 antibody (AA 212-341)

Catalog No. ABIN7148902

Product Details anti-CDK7 Antibody

Target: CDK7 (Cyclin-Dependent Kinase 7 (CDK7))

Binding Specificity: AA 212-341

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK7 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cyclin-dependent kinase 7 protein (212-341AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CDK7

Target: CDK7 (Cyclin-Dependent Kinase 7 (CDK7))

Alternative Name: CDK7 (CDK7 Products)

Synonyms: CAK1 antibody, CDKN7 antibody, HCAK antibody, MO15 antibody, STK1 antibody, p39MO15 antibody, AI323415 antibody, AI528512 antibody, C230069N13 antibody, Cdkn7 antibody, Crk4 antibody, CD 7 antibody, CDK7 antibody, CG3319 antibody, DmCDK7 antibody, DmCdk7 antibody, DmMO15 antibody, DmMo15 antibody, Dmcdk7 antibody, Dmel\\CG3319 antibody, Mo15 antibody, cdk-7 antibody, cdk7 antibody, dCdk7 antibody, p40[MO15] antibody, p40MO15 antibody, stk1 antibody, zgc:85821 antibody, cak1 antibody, cdkn7 antibody, p39mo15 antibody, cyclin dependent kinase 7 antibody, cyclin-dependent kinase 7 antibody, Cyclin-dependent kinase 7 antibody, cyclin-dependent kinase 7 L homeolog antibody, CDK7 antibody, Cdk7 antibody, cdk7.L antibody, cdk7 antibody

Background:

Background: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53, this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.

Aliases: 39 kDa protein kinase antibody, CAK antibody, CAK1 antibody, Cdk activating kinase antibody, CDK-activating kinase 1 antibody, CDK-activating kinase antibody, cdk7 antibody, CDK7_HUMAN antibody, CDKN7 antibody, Cell division protein kinase 7 antibody, Cyclin dependent kinase 7 antibody, cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) antibody, Cyclin-dependent kinase 7 antibody, HCAK antibody, Homolog of Xenopus MO15 Cdk activating kinase antibody, Kinase subunit of CAK antibody, MO15 antibody, MO15, Xenopus, homolog of antibody, P39 Mo15 antibody, p39MO15 antibody, Serine threonine kinase Stk1 antibody, Serine/threonine protein kinase 1 antibody, Serine/threonine protein kinase MO15 antibody, STK1 antibody, TFIIH basal transcription factor complex kinase subunit antibody

UniProt: P50613

Pathways: Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, M Phase