ATF5 antibody (AA 1-282)

Catalog No. ABIN7148801

Product Details anti-ATF5 Antibody

Target: ATF5 (Activating Transcription Factor 5 (ATF5))

Binding Specificity: AA 1-282

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATF5 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Cyclic AMP-dependent transcription factor ATF-5 protein (1-282AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ATF5

Target: ATF5 (Activating Transcription Factor 5 (ATF5))

Alternative Name: ATF5 (ATF5 Products)

Synonyms: ATF5 antibody, atfx antibody, hmfn0395 antibody, ATFX antibody, HMFN0395 antibody, AFTA antibody, Atf7 antibody, Atfx antibody, ODA-10 antibody, atf5 antibody, activating transcription factor 5 antibody, activating transcription factor 5, gene 2 S homeolog antibody, ATF5 antibody, atf5 antibody, Atf5 antibody, atf5.2.S antibody

Background:

Background: Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5\'-GTGACGT[AC][AG]-3\'), ATF5-specific response element (ARE) (consensus: 5\'-C[CT]TCT[CT]CCTT[AT]-3\') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).

Aliases: ATF5 antibody, ATFXCyclic AMP-dependent transcription factor ATF-5 antibody, cAMP-dependent transcription factor ATF-5 antibody, Activating transcription factor 5 antibody, Transcription factor ATFx antibody

UniProt: Q9Y2D1

Pathways: Myometrial Relaxation and Contraction