CELF2 antibody (AA 291-381)

Catalog No. ABIN7148735

Product Details anti-CELF2 Antibody

Target: CELF2 (CUGBP, Elav-Like Family Member 2 (CELF2))

Binding Specificity: AA 291-381

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CELF2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human CUGBP Elav-like family member 2 protein (291-381AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CELF2

Target: CELF2 (CUGBP, Elav-Like Family Member 2 (CELF2))

Alternative Name: CELF2 (CELF2 Products)

Synonyms: CUGBP2 antibody, BRUNOL3 antibody, ETR-3 antibody, ETR3 antibody, NAPOR antibody, B230218O03 antibody, B230345P09Rik antibody, C88023 antibody, CELF-2 antibody, CUG-BP2 antibody, Cugbp2 antibody, D230046B21Rik antibody, Etr-3 antibody, Napor antibody, Napor-2 antibody, mETR-3 antibody, cb906 antibody, cugbp2 antibody, fj87b07 antibody, wu:fj87b07 antibody, brunol3 antibody, celf2 antibody, cugbp2-a antibody, etr3 antibody, napor antibody, Brunol3 antibody, Etr3 antibody, CUGBP Elav-like family member 2 antibody, CUGBP, Elav-like family member 2 antibody, cugbp, Elav-like family member 2 antibody, CUGBP, Elav-like family member 2 L homeolog antibody, CELF2 antibody, Celf2 antibody, celf2 antibody, celf2.L antibody

Background:

Background: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3\\\'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3\\\'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity).

Aliases: Bruno-like protein 3 antibody, BRUNOL3 antibody, Cardiac elav type RNA binding protein antibody, CELF-2 antibody, celf2 antibody, CELF2_HUMAN antibody, CUG BP2 antibody, CUG triplet repeat RNA-binding protein 2 antibody, CUG-BP- and ETR-3-like factor 2 antibody, CUG-BP2 antibody, CUGBP Elav like family member 2 antibody, CUGBP Elav-like family member 2 antibody, CUGBP2 antibody, dJ323N1.1 antibody, elav type RNA binding protein antibody, ELAV-type RNA-binding protein 3 antibody, ETR 3 antibody, ETR-3 antibody, ETR3 antibody, HGNC:2550 antibody, hNAPOR antibody, NAPOR 2 antibody, NAPOR antibody, Neuroblastoma apoptosis-related RNA-binding protein antibody, Neuroplastoma apoptosis related RNA binding protein 3 antibody, RNA binding protein BRUNOL3 antibody, RNA-binding protein BRUNOL-3 antibody

UniProt: O95319

Pathways: Ribonucleoprotein Complex Subunit Organization