CRTC2 antibody (AA 180-372) (Biotin)

Catalog No. ABIN7148680

Product Details anti-CRTC2 Antibody (Biotin)

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Binding Specificity: AA 180-372

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRTC2 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human CREB-regulated transcription coactivator 2 protein (180-372AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CRTC2

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Alternative Name: CRTC2 (CRTC2 Products)

Synonyms: CRTC2 antibody, TORC-2 antibody, TORC2 antibody, 4632407F12Rik antibody, Torc2 antibody, mTORC2 antibody, RGD1308903 antibody, CREB regulated transcription coactivator 2 antibody, CRTC2 antibody, Crtc2 antibody

Background:

Background: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 \'Ser-133\' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Aliases: CREB regulated transcription coactivator 2 antibody, CREB-regulated transcription coactivator 2 antibody, CRTC2 antibody, CRTC2_HUMAN antibody, RP11-422P24.6 antibody, TORC-2 antibody, torc2 antibody, Transducer of CREB protein 2 antibody, Transducer of regulated cAMP response element-binding protein antibody, Transducer of regulated cAMP response element-binding protein (CREB) 2 antibody, Transducer of regulated cAMP response element-binding protein 2 antibody, Transducer of regulated CREB protein 2 antibody

UniProt: Q53ET0

Pathways: AMPK Signaling, Carbohydrate Homeostasis