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H2AFY antibody (AA 123-372)

H2AFY Reactivity: Human WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7148560
  • Target See all H2AFY Antibodies
    H2AFY (H2A Histone Family, Member Y (H2AFY))
    Binding Specificity
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 123-372
    Reactivity
    • 23
    • 19
    • 18
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 23
    Rabbit
    Clonality
    • 14
    • 9
    Polyclonal
    Conjugate
    • 16
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This H2AFY antibody is un-conjugated
    Application
    • 16
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Cross-Reactivity
    Human
    Purification
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Core histone macro-H2A.1 protein (123-372AA)
    Isotype
    IgG
    Top Product
    Discover our top product H2AFY Primary Antibody
  • Application Notes
    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    H2AFY (H2A Histone Family, Member Y (H2AFY))
    Alternative Name
    H2AFY (H2AFY Products)
    Synonyms
    H2A.y antibody, H2A/y antibody, H2AF12M antibody, H2AFJ antibody, MACROH2A1.1 antibody, mH2A1 antibody, macroH2A1.2 antibody, mH2a1 antibody, macroH2A1 antibody, wu:fa93c12 antibody, zgc:136891 antibody, h2a.y antibody, h2a/y antibody, h2af12m antibody, h2afj antibody, macroh2a antibody, mh2a1 antibody, core histone macro-H2A.1 antibody, H2A histone family, member Y antibody, H2A histone family member Y antibody, H2A histone family member Y L homeolog antibody, LOC100230612 antibody, H2AFY antibody, LOC481514 antibody, H2afy antibody, h2afy antibody, h2afy.L antibody
    Background

    Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.

    Aliases: Core histone macro h2a.1 antibody, Core histone macro-H2A.1 antibody, H2A histone family member Y antibody, H2A.y antibody, H2A/y antibody, H2AF12M antibody, H2AFJ antibody, H2afy antibody, H2AY_HUMAN antibody, Histone H2A.Y antibody, Histone macroH2A1 antibody, Histone macroH2A1.1 antibody, Histone macroH2A1.2 antibody, Macroh2a1 antibody, MACROH2A1.1 antibody, MacroH2A1.2 antibody, Medulloblastoma antigen MU MB 50.205 antibody, Medulloblastoma antigen MU-MB-50.205 antibody, mH2a antibody, mH2A1 antibody

    UniProt
    O75367
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