COPS8 antibody (AA 150-198) (HRP)

Catalog No. ABIN7148510

Product Details anti-COPS8 Antibody (HRP)

Target: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Binding Specificity: AA 150-198

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS8 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human COP9 signalosome complex subunit 8 protein (150-198AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for COPS8

Target: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Alternative Name: COPS8 (COPS8 Products)

Background:

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Aliases: COP9 homolog antibody, COP9 signalosome complex subunit 8 antibody, COP9 signalosome subunit 8 antibody, Cops8 antibody, CSN8 antibody, CSN8_HUMAN antibody, hCOP9 antibody, JAB1 containing signalosome subunit 8 antibody, JAB1-containing signalosome subunit 8 antibody, SGN8 antibody, Signalosome subunit 8 antibody

UniProt: Q99627

Pathways: Cell Division Cycle