COPS7B antibody (AA 1-157) (Biotin)

Catalog No. ABIN7148504

Product Details anti-COPS7B Antibody (Biotin)

Target: COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))

Binding Specificity: AA 1-157

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS7B antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human COP9 signalosome complex subunit 7b protein (1-157AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for COPS7B

Target: COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))

Alternative Name: COPS7B (COPS7B Products)

Synonyms: MGC114836 antibody, D1Wsu66e antibody, E130114M23 antibody, CSN7B antibody, COP9 signalosome subunit 7B antibody, COP9 signalosome subunit 7B S homeolog antibody, Cops7b antibody, COPS7B antibody, cops7b.S antibody

Background:

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Aliases: COP9 Complex Homolog Subunit 7b antibody, COP9 Constitutive Photomorphogenic Homolog Subunit 7b antibody, COP9 Signalasome Subunit 7b antibody, COP9 signalosome complex subunit 7b antibody, COPS7B antibody, CSN7B_HUMAN antibody, JAB1 Containing Signalosome Subunit 7b antibody, JAB1-containing signalosome subunit 7b antibody, SGN7b antibody, Signalosome subunit 7b antibody

UniProt: Q9H9Q2

Pathways: Cell Division Cycle