COPS4 antibody (AA 1-310)

Catalog No. ABIN7148496

Product Details anti-COPS4 Antibody

Target: COPS4 (COP9 Signalosome Subunit 4 (COPS4))

Binding Specificity: AA 1-310

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human COP9 signalosome complex subunit 4 protein (1-310AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for COPS4

Target: COPS4 (COP9 Signalosome Subunit 4 (COPS4))

Alternative Name: COPS4 (COPS4 Products)

Background:

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Aliases: CH4 antibody, COP9 (constitutive photomorphogenic) homolog subunit 4 antibody, COP9 complex homolog subunit 4 antibody, COP9 complex S4 antibody, COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) antibody, COP9 constitutive photomorphogenic homolog subunit 4 antibody, COP9 signalosome complex subunit 4 antibody, COP9 signalosome subunit 4 antibody, COPS4 antibody, CSN complex subunit 4 antibody, CSN4 antibody, CSN4 SCHPO antibody, CSN4_HUMAN antibody, DCH4 antibody, JAB1 containing signalosome subunit 4 antibody, JAB1-containing signalosome subunit 4 antibody, MGC94896 antibody, SGN4 antibody, Signalosome subunit 4 antibody

UniProt: Q9BT78

Pathways: Cell Division Cycle