COPS3 antibody (AA 194-423)
-
- Target See all COPS3 Antibodies
- COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))
-
Binding Specificity
- AA 194-423
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This COPS3 antibody is un-conjugated
-
Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Cross-Reactivity
- Human, Mouse
- Purification
- Antigen Affinity Purified
- Immunogen
- Recombinant Human COP9 signalosome complex subunit 3 protein (194-423AA)
- Isotype
- IgG
- Top Product
- Discover our top product COPS3 Primary Antibody
-
-
- Application Notes
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- Target
- COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))
- Alternative Name
- COPS3 (COPS3 Products)
- Background
-
Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Aliases: Constitutive photomorphogenic homolog subunit 3 antibody, COP 9 (constitutive photomorphogenic) subunit 3 antibody, COP 9 complex homolog subunit 3 antibody, COP 9 complex S3 antibody, COP 9 complex subunit 3 antibody, COP 9 constitutive photomorphogenic homolog subunit 3 antibody, COP 9 homolog antibody, COP 9 signalosome complex subunit 3 antibody, COP 9 signalosome subunit 3 antibody, COP 9 subunit 3 antibody, COP9 (constitutive photomorphogenic) subunit 3 antibody, COP9 complex homolog subunit 3 antibody, COP9 complex S3 antibody, COP9 complex subunit 3 antibody, COP9 constitutive photomorphogenic homolog subunit 3 antibody, COP9 homolog antibody, COP9 signalosome complex subunit 3 antibody, COP9 signalosome subunit 3 antibody, COP9 subunit 3 antibody, COPS 3 antibody, cops3 antibody, CSN 3 antibody, CSN3 antibody, CSN3_HUMAN antibody, JAB 1 containing signalosome subunit 3 antibody, JAB1 containing signalosome subunit 3 antibody, JAB1-containing signalosome subunit 3 antibody, SGN 3 antibody, SGN3 antibody, Signalosome subunit 3 antibody
- UniProt
- Q9UNS2
- Pathways
- Cell Division Cycle
-