GPS1 antibody (AA 222-491)

Catalog No. ABIN7148491

Product Details anti-GPS1 Antibody

Target: GPS1 (G Protein Pathway Suppressor 1 (GPS1))

Binding Specificity: AA 222-491

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human COP9 signalosome complex subunit 1 protein (222-491AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GPS1

Target: GPS1 (G Protein Pathway Suppressor 1 (GPS1))

Alternative Name: GPS1 (GPS1 Products)

Background:

Background: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Aliases: COP9 signalosome complex subunit 1 antibody, COP9 signalosome subunit 1 antibody, COPS1 antibody, CSN 1 antibody, CSN1_HUMAN antibody, FUS6/COP11, Arabidopsis, homolog of antibody, G protein pathway suppressor 1 antibody, GPS-1 antibody, Gps1 antibody, JAB1-containing signalosome subunit 1 antibody, Protein GPS1 antibody, Protein MFH antibody, SGN1 antibody, Signalosome subunit 1 antibody

UniProt: Q13098

Pathways: Cell Division Cycle