MCC antibody (AA 479-611) (HRP)
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- Target See all MCC Antibodies
- MCC (Mutated in Colorectal Cancers (MCC))
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Binding Specificity
- AA 479-611
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MCC antibody is conjugated to HRP
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Application
- ELISA
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Colorectal mutant cancer protein (479-611AA)
- Isotype
- IgG
- Top Product
- Discover our top product MCC Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- MCC (Mutated in Colorectal Cancers (MCC))
- Alternative Name
- MCC (MCC Products)
- Synonyms
- MCC antibody, mcc1 antibody, MCC1 antibody, D18Ertd451e antibody, E330037C19 antibody, RGD1561988 antibody, mutated in colorectal cancers antibody, MCC antibody, mcc antibody, Mcc antibody
- Background
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Background: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).
Aliases: Colorectal mutant cancer protein antibody, CRCM_HUMAN antibody, DKFZp762O1615 antibody, FLJ38893 antibody, FLJ46755 antibody, MCC 1 antibody, MCC antibody, MCC1 antibody, Mutated in colorectal cancers antibody, Protein MCC antibody
- UniProt
- P23508
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