COPB1 antibody (AA 2-200)

Catalog No. ABIN7148009

Product Details anti-COPB1 Antibody

Target: COPB1 (Coatomer Protein Complex, Subunit beta 1 (COPB1))

Binding Specificity: AA 2-200

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Coatomer subunit beta protein (2-200AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for COPB1

Target: COPB1 (Coatomer Protein Complex, Subunit beta 1 (COPB1))

Alternative Name: COPB1 (COPB1 Products)

Synonyms: id:ibd5034 antibody, wu:fc66c05 antibody, zgc:92482 antibody, COPB1 antibody, DKFZp459K154 antibody, COPB antibody, 2610019B04Rik antibody, Rack2 antibody, Beta-COP antibody, coatomer protein complex, subunit beta 1 antibody, coatomer protein complex subunit beta 1 L homeolog antibody, coatomer protein complex subunit beta 1 antibody, copb1 antibody, copb1.L antibody, COPB1 antibody, Copb1 antibody

Background:

Background: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins, the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments.

Aliases: Beta-coat protein antibody, Beta-COP antibody, betacop antibody, Coatomer beta subunit antibody, Coatomer protein complex subunit beta 1 antibody, Coatomer protein complex subunit beta antibody, Coatomer subunit beta antibody, COPB antibody, COPB_HUMAN antibody, Copb1 antibody, DKFZp761K102 antibody, FLJ10341 antibody

UniProt: P53618