Clusterin antibody (AA 23-224)

Catalog No. ABIN7147944

Product Details anti-Clusterin Antibody

Target: Clusterin (CLU)

Binding Specificity: AA 23-224

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Clusterin antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Clusterin protein (23-224AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Clusterin

Target: Clusterin (CLU)

Alternative Name: CLU (CLU Products)

Synonyms: LOC100136120 antibody, clu antibody, MGC53055 antibody, zgc:73352 antibody, xclu antibody, MGC89163 antibody, CLU antibody, APO-J antibody, APOJ antibody, CLI antibody, CLU1 antibody, CLU2 antibody, KUB1 antibody, NA1/NA2 antibody, SGP-2 antibody, SGP2 antibody, SP-40 antibody, TRPM-2 antibody, TRPM2 antibody, DAG antibody, RATTRPM2B antibody, SP40 antibody, TRPM2B antibody, Trpm2 antibody, Trpmb antibody, AI893575 antibody, ApoJ antibody, Cli antibody, D14Ucla3 antibody, Sgp-2 antibody, Sgp2 antibody, Sugp-2 antibody, GP80 antibody, gpIII antibody, 40 antibody, clusterin-1 antibody, clusterin L homeolog antibody, clusterin antibody, Clusterin antibody, LOC100136120 antibody, clu.L antibody, clu antibody, CLU antibody, clus antibody, Clu antibody, LOC101113728 antibody

Background:

Background: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

Aliases: 40 antibody, AAG 4 antibody, AAG4 antibody, Aging associated protein 4 antibody, Aging-associated gene 4 protein antibody, AI893575 antibody, APO J antibody, Apo-J antibody, APOJ antibody, ApoJalpha antibody, ApoJbeta antibody, Apolipoprotein J antibody, ApolipoproteinJ antibody, CLI antibody, CLU antibody, CLU1 antibody, CLU2 antibody, CLUS_HUMAN antibody, Clusterin alpha chain antibody, Clusterin antibody, Clusterin beta chain antibody, Complement associated protein SP 40 40 antibody, Complement associated protein SP 40 antibody, Complement associated protein SP40 antibody, Complement cytolysis inhibitor a chain antibody, Complement cytolysis inhibitor antibody, Complement cytolysis inhibitor b chain antibody, Complement lysis inhibitor antibody, Complement-associated protein SP-40 antibody, D14Ucla3 antibody, Dimeric acid glycoprotein antibody, Glycoprotein 80 antibody, Glycoprotein III antibody, GP80 antibody, Ku70-binding protein 1 antibody, KUB 1 antibody, KUB1 antibody, MGC24903 antibody, NA1/NA2 antibody, RATTRPM2B antibody, SGP 2 antibody, SGP2 antibody, SP 40 antibody, SP40 antibody, Sugp-2 antibody, Sulfated glycoprotein 2 antibody, Testosterone repressed prostate message 2 antibody, Testosterone-repressed prostate message 2 antibody, TRPM 2 antibody, TRPM-2 antibody, TRPM2 antibody, TRPM2B antibody, Trpmb antibody

UniProt: P10909

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling