CLASP2 antibody (AA 226-381) (Biotin)

Catalog No. ABIN7147937

Product Details anti-CLASP2 Antibody (Biotin)

Target: CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))

Binding Specificity: AA 226-381

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLASP2 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human CLIP-associating protein 2 protein (226-381AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CLASP2

Target: CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))

Alternative Name: CLASP2 (CLASP2 Products)

Synonyms: zgc:77279 antibody, DKFZp459M112 antibody, 1500004F14Rik antibody, 8030404L10Rik antibody, C77448 antibody, CLASP2beta antibody, mKIAA0627 antibody, cytoplasmic linker associated protein 2 antibody, CLIP associating protein 2 antibody, clasp2 antibody, CLASP2 antibody, Clasp2 antibody

Background:

Background: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.

Aliases: CLAP2_HUMAN antibody, CLASP 2 antibody, Clasp2 antibody, CLIP associating protein 2 antibody, CLIP-associating protein 2 antibody, Cytoplasmic linker associated protein 2 antibody, Cytoplasmic linker-associated protein 2 antibody, hOrbit2 antibody, KIAA0627 antibody, Multiple asters (Mast) like homolog 2 antibody, Protein Orbit homolog 2 antibody

UniProt: O75122

Pathways: Microtubule Dynamics, Maintenance of Protein Location