BHLHE41 antibody (AA 185-285) (Biotin)

Catalog No. ABIN7147842

Product Details anti-BHLHE41 Antibody (Biotin)

Target: BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))

Binding Specificity: AA 185-285

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BHLHE41 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Class E basic helix-loop-helix protein 41 protein (185-285AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BHLHE41

Target: BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))

Alternative Name: BHLHE41 (BHLHE41 Products)

Synonyms: BHLHB3 antibody, dec2 antibody, bhlhb3 antibody, sharp1 antibody, sharp-1 antibody, MGC108143 antibody, DEC2 antibody, SHARP1 antibody, hDEC2 antibody, 6430520M22Rik antibody, Bhlhb2l antibody, Bhlhb3 antibody, Sharp1 antibody, Dec2 antibody, SHARP-1 antibody, basic helix-loop-helix family member e41 antibody, basic helix-loop-helix family, member e41 antibody, BHLHE41 antibody, bhlhe41 antibody, Bhlhe41 antibody

Background:

Background: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5\'-CACGTG-3\') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.

Aliases: Basic helix-loop-helix domain containing class B3 antibody, BHE41_HUMAN antibody, bHLH protein DEC2 antibody, bHLHB3 antibody, bHLHe41 antibody, Class B basic helix loop helix protein 3 antibody, Class B basic helix-loop-helix protein 3 antibody, Class E basic helix-loop-helix protein 41 antibody, DEC2 antibody, Differentially expressed in chondrocytes protein 2 antibody, Enhancer of split and hairy related protein 1 antibody, Enhancer-of-split and hairy-related protein 1 antibody, hDEC2 antibody, Moderately similar to basic-helix loop helix protein M.musculus antibody, SHARP-1 antibody

UniProt: Q9C0J9

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development