IRG1 antibody (AA 57-257) (Biotin)

Catalog No. ABIN7147802

Product Details anti-IRG1 Antibody (Biotin)

Target: IRG1 (Immunoresponsive Gene 1 (IRG1))

Binding Specificity: AA 57-257

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRG1 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cis-aconitate decarboxylase protein (57-257AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IRG1

Target: IRG1 (Immunoresponsive Gene 1 (IRG1))

Alternative Name: ACOD1 (IRG1 Products)

Synonyms: CAD antibody, AI323667 antibody, aconitate decarboxylase 1 antibody, ACOD1 antibody, Acod1 antibody

Background:

Background: Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells, ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.

Aliases: ACOD1 antibody, Aconitate decarboxylase 1 antibody, Aconitate decarboxylase antibody, CAD antibody, Cis aconitate decarboxylase antibody, Immune responsive gene 1 protein homolog antibody, Immune-responsive gene 1 protein homolog antibody, Immunoresponsive 1 homolog (mouse) antibody, Irg1 antibody, IRG1_HUMAN antibody, OC116 antibody, OPTB1 antibody, TCTIRC7 antibody

UniProt: A6NK06