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CHD5 antibody (AA 1600-1699)

CHD5 Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7147724
  • Target See all CHD5 Antibodies
    CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))
    Binding Specificity
    • 4
    • 3
    • 3
    • 1
    • 1
    AA 1600-1699
    Reactivity
    • 19
    • 3
    • 1
    Human
    Host
    • 17
    • 1
    • 1
    Rabbit
    Clonality
    • 18
    • 1
    Polyclonal
    Conjugate
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CHD5 antibody is un-conjugated
    Application
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Chromodomain-helicase-DNA-binding protein 5 protein (1600-1699AA)
    Isotype
    IgG
  • Application Notes
    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))
    Alternative Name
    CHD5 (CHD5 Products)
    Synonyms
    CHD-5 antibody, 4930532L22Rik antibody, AW060752 antibody, B230399N07Rik antibody, CHD5 antibody, chromodomain helicase DNA binding protein 5 antibody, potassium voltage-gated channel subfamily A regulatory beta subunit 2 antibody, CHD5 antibody, Chd5 antibody, chd5 antibody, KCNAB2 antibody
    Background

    Background: Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated \'Lys-27\' (H3K27me3) and non-methylated \'Lys-4\' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at \'Lys-27\' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.

    Aliases: ATP-dependent helicase CHD5 antibody, CHD 5 antibody, CHD-5 antibody, CHD5 antibody, CHD5_HUMAN antibody, Chromodomain-helicase-DNA-binding protein 5 antibody, DKFZp434N231 antibody, KIAA0444 antibody, RP1-233K16.2 antibody

    UniProt
    Q8TDI0
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