CHMP5 antibody (AA 1-219)

Catalog No. ABIN7147529

Product Details anti-CHMP5 Antibody

Target: CHMP5 (Charged Multivesicular Body Protein 5 (CHMP5))

Binding Specificity: AA 1-219

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHMP5 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Charged multivesicular body protein 5 protein (1-219AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000, IF:1:100-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CHMP5

Target: CHMP5 (Charged Multivesicular Body Protein 5 (CHMP5))

Alternative Name: CHMP5 (CHMP5 Products)

Synonyms: SNF7DC2 antibody, cgi-34 antibody, hspc177 antibody, pnas-2 antibody, vps60 antibody, chmp5 antibody, zgc:64125 antibody, C9orf83 antibody, HSPC177 antibody, PNAS-2 antibody, Vps60 antibody, 2210412K09Rik antibody, AW545668 antibody, RGD1305968 antibody, charged multivesicular body protein 5 S homeolog antibody, charged multivesicular body protein 5b antibody, charged multivesicular body protein 5 antibody, charged multivesicular body protein 5 L homeolog antibody, chromatin modifying protein 5 antibody, chmp5.S antibody, chmp5b antibody, CHMP5 antibody, chmp5.L antibody, chmp5 antibody, Chmp5 antibody

Background:

Background: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Aliases: apoptosis-related protein PNAS-2 antibody, C9orf83 antibody, CGI 34 antibody, Charged multivesicular body protein 5 antibody, CHMP 5 antibody, CHMP family, member 5 antibody, chmp5 antibody, CHMP5_HUMAN antibody, Chromatin modifying protein 5 antibody, Chromatin-modifying protein 5 antibody, Chromosome 9 open reading frame 83 antibody, HGNC:26942 antibody, HSPC177 antibody, hVps60 antibody, PNAS 2 antibody, SNF7 domain containing protein 2 antibody, SNF7 domain-containing protein 2 antibody, SNF7DC2 antibody, Vacuolar protein sorting 60 antibody, Vacuolar protein sorting-associated protein 60 antibody, Vps60 antibody

UniProt: Q9NZZ3