CETN2 antibody (AA 1-172) (Biotin)

Catalog No. ABIN7147354

Product Details anti-CETN2 Antibody (Biotin)

Target: CETN2 (Centrin, EF-Hand Protein, 2 (CETN2))

Binding Specificity: AA 1-172

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CETN2 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Centrin-2 protein (1-172AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CETN2

Target: CETN2 (Centrin, EF-Hand Protein, 2 (CETN2))

Alternative Name: CETN2 (CETN2 Products)

Synonyms: cb732 antibody, CETN2 antibody, 1110034A02Rik antibody, AI326150 antibody, Calt antibody, caltractin antibody, CALT antibody, CEN2 antibody, caltractin antibody, centrin 2 antibody, centrin 4 antibody, LOC412449 antibody, CETN2 antibody, cetn4 antibody, Cetn2 antibody

Background:

Background: Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.RInvolved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5\'-to-3\' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.

Aliases: 20kD calcium binding protein antibody, CALT antibody, caltractin antibody, Caltractin isoform 1 antibody, CEN2 antibody, centrin antibody, centrin, EF hand protein, 2 antibody, Centrin-2 antibody, Centrin2 antibody, CETN2 antibody, CETN2_HUMAN antibody, EF hand protein 2 antibody, EF-hand protein antibody

UniProt: P41208

Pathways: DNA Damage Repair, M Phase