CNOT8 antibody (AA 1-292)

Catalog No. ABIN7147105

Product Details anti-CNOT8 Antibody

Target: CNOT8 (CCR4-NOT Transcription Complex, Subunit 8 (CNOT8))

Binding Specificity: AA 1-292

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNOT8 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human CCR4-NOT transcription complex subunit 8 protein (1-292AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CNOT8

Target: CNOT8 (CCR4-NOT Transcription Complex, Subunit 8 (CNOT8))

Alternative Name: CNOT8 (CNOT8 Products)

Synonyms: calif antibody, pop2 antibody, zgc:63844 antibody, wu:fe49a05 antibody, caf1 antibody, hcaf1 antibody, CAF1 antibody, CALIF antibody, Caf1b antibody, POP2 antibody, hCAF1 antibody, 1500015I04Rik antibody, 1810022F04Rik antibody, AA536816 antibody, AU015770 antibody, AU043059 antibody, CCR4-NOT transcription complex, subunit 8 antibody, CCR4-NOT transcription complex subunit 8 antibody, CCR4-NOT transcription complex subunit 8 S homeolog antibody, Cnot8 antibody, CNOT8 antibody, cnot8.S antibody, cnot8 antibody, PAAG_04884 antibody, VDBG_08730 antibody

Background:

Background: Has 3\\\'-5\\\' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Aliases: CAF 1 antibody, CAF 2 antibody, CAF1 antibody, CAF1 like protein antibody, CAF1-like protein antibody, CAF2 antibody, CALIF antibody, CALIFp antibody, CCR4 associated factor 8 antibody, CCR4 NOT transcription complex subunit 8 antibody, CCR4-associated factor 8 antibody, CCR4-NOT transcription complex subunit 8 antibody, CNOT 8 antibody, Cnot8 antibody, CNOT8_HUMAN antibody, hCAF1 antibody, PGK promoter directed over production antibody, POP 2 antibody, POP2 antibody

UniProt: Q9UFF9