CNOT3 antibody (AA 257-395) (HRP)

Catalog No. ABIN7147104

Product Details anti-CNOT3 Antibody (HRP)

Target: CNOT3 (CCR4-NOT Transcription Complex, Subunit 3 (CNOT3))

Binding Specificity: AA 257-395

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNOT3 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human CCR4-NOT transcription complex subunit 3 protein (257-395AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CNOT3

Target: CNOT3 (CCR4-NOT Transcription Complex, Subunit 3 (CNOT3))

Alternative Name: CNOT3 (CNOT3 Products)

Background:

Background: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation, may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation, the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.

Aliases: CCR4 associated factor 3 antibody, CCR4-associated factor 3 antibody, CCR4-NOT transcription complex subunit 3 antibody, CNOT3 antibody, CNOT3_HUMAN antibody, KIAA0691 antibody, LENG2 antibody, Leukocyte receptor cluster member 2 antibody, negative regulator of transcription 3, S. cerevisiae, homolog of antibody, NOT3 (negative regulator of transcription 3, yeast) homolog antibody, NOT3 antibody, NOT3H antibody

UniProt: O75175

Pathways: Stem Cell Maintenance