CNOT1 antibody (AA 604-867)
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- Target See all CNOT1 Antibodies
- CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
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Binding Specificity
- AA 604-867
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CNOT1 antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human CCR4-NOT transcription complex subunit 1 protein (604-867AA)
- Isotype
- IgG
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- Application Notes
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
- Alternative Name
- CNOT1 (CNOT1 Products)
- Synonyms
- CDC39 antibody, NOT1 antibody, NOT1H antibody, 6030411K04Rik antibody, AA815922 antibody, D830048B13 antibody, RGD1308009 antibody, GB18988 antibody, cdc39-like antibody, im:7141761 antibody, kiaa1007l antibody, wu:fc58h04 antibody, zgc:152902 antibody, CNOT1 antibody, not1 antibody, cdc39 antibody, not1h antibody, ad-005 antibody, NV18106 antibody, CCR4-NOT transcription complex subunit 1 antibody, CCR4-NOT transcription complex, subunit 1 antibody, CNOT1 antibody, Cnot1 antibody, LOC412371 antibody, cnot1 antibody, LOC100114396 antibody
- Background
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Background: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3\'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.
Aliases: CNOT1 antibody, CDC39 antibody, KIAA1007 antibody, NOT1 antibody, AD-005CCR4-NOT transcription complex subunit 1 antibody, CCR4-associated factor 1 antibody, Negative regulator of transcription subunit 1 homolog antibody, NOT1H antibody, hNOT1 antibody
- UniProt
- A5YKK6
- Pathways
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance
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