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CNOT1 antibody (AA 604-867)

CNOT1 Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7147089
  • Target See all CNOT1 Antibodies
    CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
    Binding Specificity
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 604-867
    Reactivity
    • 16
    • 2
    • 1
    Human
    Host
    • 15
    • 1
    Rabbit
    Clonality
    • 16
    Polyclonal
    Conjugate
    • 9
    • 3
    • 2
    • 2
    This CNOT1 antibody is un-conjugated
    Application
    • 12
    • 7
    • 4
    • 2
    • 2
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human CCR4-NOT transcription complex subunit 1 protein (604-867AA)
    Isotype
    IgG
  • Application Notes
    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
    Alternative Name
    CNOT1 (CNOT1 Products)
    Synonyms
    CDC39 antibody, NOT1 antibody, NOT1H antibody, 6030411K04Rik antibody, AA815922 antibody, D830048B13 antibody, RGD1308009 antibody, GB18988 antibody, cdc39-like antibody, im:7141761 antibody, kiaa1007l antibody, wu:fc58h04 antibody, zgc:152902 antibody, CNOT1 antibody, not1 antibody, cdc39 antibody, not1h antibody, ad-005 antibody, NV18106 antibody, CCR4-NOT transcription complex subunit 1 antibody, CCR4-NOT transcription complex, subunit 1 antibody, CNOT1 antibody, Cnot1 antibody, LOC412371 antibody, cnot1 antibody, LOC100114396 antibody
    Background

    Background: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3\'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.

    Aliases: CNOT1 antibody, CDC39 antibody, KIAA1007 antibody, NOT1 antibody, AD-005CCR4-NOT transcription complex subunit 1 antibody, CCR4-associated factor 1 antibody, Negative regulator of transcription subunit 1 homolog antibody, NOT1H antibody, hNOT1 antibody

    UniProt
    A5YKK6
    Pathways
    Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance
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