CATSPER4 antibody (AA 306-472) (Biotin)

Catalog No. ABIN7147036

Product Details anti-CATSPER4 Antibody (Biotin)

Target: CATSPER4 (Cation Channel, Sperm Associated 4 (CATSPER4))

Binding Specificity: AA 306-472

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CATSPER4 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cation channel sperm-associated protein 4 protein (306-472AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CATSPER4

Target: CATSPER4 (Cation Channel, Sperm Associated 4 (CATSPER4))

Alternative Name: CATSPER4 (CATSPER4 Products)

Synonyms: RGD1565213 antibody, 4933412L05 antibody, cation channel, sperm associated 4 antibody, cation channel sperm associated 4 antibody, Catsper4 antibody, CATSPER4 antibody

Background:

Background: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials, it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH .

Aliases: CATSPER4Cation channel sperm-associated protein 4 antibody, CatSper4 antibody

UniProt: Q7RTX7