CATSPER2 antibody (AA 5-112)

Catalog No. ABIN7147031

Product Details anti-CATSPER2 Antibody

Target: CATSPER2 (Cation Channel, Sperm Associated 2 (CATSPER2))

Binding Specificity: AA 5-112

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CATSPER2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cation channel sperm-associated protein 2 protein (5-112AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CATSPER2

Target: CATSPER2 (Cation Channel, Sperm Associated 2 (CATSPER2))

Alternative Name: CATSPER2 (CATSPER2 Products)

Synonyms: CATSPER2 antibody, cation channel, sperm associated 2 antibody, cation channel sperm associated 2 antibody, CATSPER2 antibody, Catsper2 antibody

Background:

Background: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials, it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH .

Aliases: CATSPER2 antibody, Cation channel sperm-associated protein 2 antibody, CatSper2 antibody

UniProt: Q96P56