Casein Kinase 1 gamma 2 antibody (Isoform gamma)

Catalog No. ABIN7146876

The Rabbit Polyclonal anti-Casein Kinase 1 gamma 2 antibody has been validated for WB, IHC, ELISA and IP. It is suitable to detect Casein Kinase 1 gamma 2 in samples from Human.

Quick Overview for Casein Kinase 1 gamma 2 antibody (Isoform gamma) (ABIN7146876)

Target: Casein Kinase 1 gamma 2 (CSNK1G2) (Casein Kinase 1, gamma 2 (CSNK1G2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Casein Kinase 1 gamma 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Product Details anti-Casein Kinase 1 gamma 2 Antibody

Binding Specificity: AA 316-415, Isoform gamma

Purpose: CSNK1G2 Antibody

Cross-Reactivity: Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Casein kinase I isoform gamma-2 protein (316-415AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Casein Kinase 1 gamma 2

Target: Casein Kinase 1 gamma 2 (CSNK1G2) (Casein Kinase 1, gamma 2 (CSNK1G2))

Alternative Name: CSNK1G2

Background:

Background: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

Aliases: Casein kinase 1, gamma 2 antibody, Casein kinase I isoform gamma 2 antibody, Casein kinase I isoform gamma-2 antibody, CK1g2 antibody, CKI gamma 2 antibody, CKI-gamma 2 antibody, CSNK1G 2 antibody, Csnk1g2 antibody, KC1G2_HUMAN antibody

UniProt: P78368

Pathways: Hedgehog Signaling