EFHA1 antibody (AA 26-247)

Catalog No. ABIN7146326

Product Details anti-EFHA1 Antibody

Target: EFHA1 (EF-Hand Domain Family, Member A1 (EFHA1))

Binding Specificity: AA 26-247

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EFHA1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Calcium uptake protein 2, mitochondrial protein (26-247AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EFHA1

Target: EFHA1 (EF-Hand Domain Family, Member A1 (EFHA1))

Alternative Name: MICU2 (EFHA1 Products)

Synonyms: 1110008L20Rik antibody, EFHA1 antibody, Efha1 antibody, RGD1309934 antibody, Smhs2 antibody, 4833427E09Rik antibody, AU041871 antibody, mitochondrial calcium uptake 2 antibody, MICU2 antibody, Micu2 antibody

Background:

Background: Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927).

Aliases: 1110008L20Rik antibody, EF hand domain containing family member A1 antibody, EF hand domain family A1 antibody, EF hand domain family member A1 antibody, EF-hand domain-containing family member A1 antibody, EFHA1 antibody, EFHA1 EF hand domain family member A1 antibody, EFHA1_HUMAN antibody, FLJ25016 antibody, FLJ34588 antibody, Smhs2 homolog antibody

UniProt: Q8IYU8