CCDC109B antibody (Regulatory Subunit)

Catalog No. ABIN7146318

Product Details anti-CCDC109B Antibody

Target: CCDC109B (Coiled-Coil Domain Containing 109B (CCDC109B))

Binding Specificity: AA 89-219, Regulatory Subunit

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC109B antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Calcium uniporter regulatory subunit MCUb, mitochondrial protein (89-219AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CCDC109B

Target: CCDC109B (Coiled-Coil Domain Containing 109B (CCDC109B))

Alternative Name: MCUB (CCDC109B Products)

Synonyms: 9030408N13Rik antibody, mitochondrial calcium uniporter dominant negative beta subunit antibody, MCUB antibody, Mcub antibody

Background:

Background: Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.

Aliases: MCUB antibody, CCDC109BCalcium uniporter regulatory subunit MCUb antibody, mitochondrial antibody, MCUb antibody, Coiled-coil domain-containing protein 109B antibody

UniProt: Q9NWR8