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ZNF224 antibody (AA 206-463)

ZNF224 Reactivity: Human ELISA, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7145868
  • Target See all ZNF224 Antibodies
    ZNF224 (Zinc Finger Protein 224 (ZNF224))
    Binding Specificity
    • 8
    • 7
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 206-463
    Reactivity
    • 28
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 25
    • 3
    Rabbit
    Clonality
    • 26
    • 2
    Polyclonal
    Conjugate
    • 12
    • 4
    • 4
    • 4
    • 2
    • 2
    This ZNF224 antibody is un-conjugated
    Application
    • 21
    • 19
    • 2
    • 1
    ELISA, Immunofluorescence (IF)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human BUB3-interacting and GLEBS motif-containing protein ZNF207 protein (206-463AA)
    Isotype
    IgG
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    Discover our top product ZNF224 Primary Antibody
  • Application Notes
    Recommended dilution: IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    ZNF224 (Zinc Finger Protein 224 (ZNF224))
    Alternative Name
    ZNF27 (ZNF224 Products)
    Synonyms
    BMZF-2 antibody, BMZF2 antibody, KOX22 antibody, ZNF255 antibody, ZNF27 antibody, zinc finger protein 224 antibody, ZNF224 antibody
    Background

    Background: Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).

    Aliases: Zinc finger protein 207 antibody, ZN207_HUMAN antibody, ZNF 207 antibody, ZNF207 antibody

    UniProt
    O43670
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