KCTD6 antibody (AA 1-237)

Catalog No. ABIN7145856

Product Details anti-KCTD6 Antibody

Target: KCTD6 (Potassium Channel Tetramerisation Domain Containing 6 (KCTD6))

Binding Specificity: AA 1-237

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCTD6 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KCTD6

Target: KCTD6 (Potassium Channel Tetramerisation Domain Containing 6 (KCTD6))

Alternative Name: KCTD6 (KCTD6 Products)

Synonyms: KCTD6 antibody, 5430433B02Rik antibody, AU044285 antibody, kctd6 antibody, zgc:91884 antibody, KCASH3 antibody, potassium channel tetramerization domain containing 6 antibody, potassium channel tetramerisation domain containing 6 antibody, potassium channel tetramerization domain containing 6b antibody, KCTD6 antibody, kctd6 antibody, Kctd6 antibody, kctd6b antibody

Background:

Background: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1, the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1, the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).

Aliases: BTB/POZ domain-containing protein KCTD6 antibody, KCASH3 antibody, kctd6 antibody, KCTD6_HUMAN antibody, MGC27385 antibody, potassium channel tetramerization domain containing 6 antibody

UniProt: Q8NC69