BRAP antibody (AA 13-124)

Catalog No. ABIN7145758

Product Details anti-BRAP Antibody

Target: BRAP (BRCA1 Associated Protein (BRAP))

Binding Specificity: AA 13-124

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRAP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human BRCA1-associated protein (13-124AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BRAP

Target: BRAP (BRCA1 Associated Protein (BRAP))

Alternative Name: BRAP (BRAP Products)

Synonyms: imp antibody, MGC68778 antibody, zgc:92894 antibody, BRAP antibody, BRAP2 antibody, IMP antibody, RNF52 antibody, 3010002G07Rik antibody, BRCA1 associated protein S homeolog antibody, BRCA1 associated protein antibody, BRCA1-associated protein antibody, brca1-associated protein antibody, brap.S antibody, brap antibody, BRAP antibody, NAEGRDRAFT_81654 antibody, CC1G_00971 antibody, CpipJ_CPIJ003557 antibody, Tsp_05101 antibody, LOC100282389 antibody, Brap antibody

Background:

Background: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

Aliases: BRAP antibody, RNF52BRCA1-associated protein antibody, EC 2.3.2.27 antibody, BRAP2 antibody, Impedes mitogenic signal propagation antibody, IMP antibody, RING finger protein 52 antibody, RING-type E3 ubiquitin transferase BRAP2 antibody, Renal carcinoma antigen NY-REN-63 antibody

UniProt: Q7Z569