BNIP3L/NIX antibody (AA 1-187)

Catalog No. ABIN7145332

Product Details anti-BNIP3L/NIX Antibody

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Binding Specificity: AA 1-187

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BNIP3L/NIX antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like protein (1-187AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BNIP3L/NIX

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Alternative Name: BNIP3L (BNIP3L Products)

Synonyms: BNIP3a antibody, NIX antibody, NIP3 antibody, Nix antibody, Nip3 antibody, C86132 antibody, D14Ertd719e antibody, Nip3L antibody, bnip3l antibody, nip3 antibody, zgc:110478 antibody, bnip3l2 antibody, wu:fb52b03 antibody, wu:fc02h04 antibody, BCL2 interacting protein 3 like antibody, BCL2 interacting protein 3 antibody, BCL2/adenovirus E1B interacting protein 3 antibody, BCL2/adenovirus E1B interacting protein 3-like antibody, BCL2/adenovirus E1B interacting protein 3-like b antibody, BCL2/adenovirus E1B interacting protein 3-like a antibody, BNIP3L antibody, BNIP3 antibody, Bnip3l antibody, Bnip3 antibody, bnip3lb antibody, bnip3la antibody

Background:

Background: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.

Aliases: Adenovirus E1B19k binding protein B5 antibody, Adenovirus E1B19K-binding protein B5 antibody, BCL2/adenovirus E1B 19 kd protein interacting protein 3a antibody, BCL2/adenovirus E1B 19 kDa protein interacting protein 3A antibody, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like antibody, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A antibody, BCL2/adenovirus E1B 19 kDa interacting protein 3 like antibody, BNI3L_HUMAN antibody, BNIP3a antibody, BNIP3H antibody, BNIP3L antibody, BNIP3L protein antibody, NIP3 like protein X antibody, NIP3-like protein X antibody, NIP3L antibody, NIX antibody

UniProt: O60238

Pathways: Autophagy