BATF antibody (AA 1-125)

Catalog No. ABIN7145275

Product Details anti-BATF Antibody

Target: BATF (Basic Leucine Zipper ATF-like Transcription Factor (BATF))

Binding Specificity: AA 1-125

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BATF antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Basic leucine zipper transcriptional factor ATF-like protein (1-125AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BATF

Target: BATF (Basic Leucine Zipper ATF-like Transcription Factor (BATF))

Alternative Name: BATF (BATF Products)

Synonyms: B-ATF antibody, si:ch211-153j24.4 antibody, BATF1 antibody, SFA-2 antibody, SFA2 antibody, basic leucine zipper transcription factor, ATF-like antibody, basic leucine zipper ATF-like transcription factor antibody, batf antibody, BATF antibody, Batf antibody

Background:

Background: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5\\\'-TGA[CG]TCA-3\\\'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5\\\'-TGAnTCA/GAAA-3\\\'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).

Aliases: Activating transcription factor B antibody, B ATF antibody, B-ATF antibody, B-cell-activating transcription factor antibody, Basic leucine zipper transcription factor like antibody, Basic leucine zipper transcriptional factor ATF like antibody, Basic leucine zipper transcriptional factor ATF-like antibody, Batf antibody, BATF_HUMAN antibody, BATF1 antibody, SF HT activated gene 2 protein antibody, SF-HT-activated gene 2 protein antibody, SFA 2 antibody, SFA-2 antibody, SFA2 antibody

UniProt: Q16520