BBS7 antibody (AA 289-393)

Catalog No. ABIN7145246

Product Details anti-BBS7 Antibody

Target: BBS7 (Bardet-Biedl Syndrome 7 (BBS7))

Binding Specificity: AA 289-393

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BBS7 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Bardet-Biedl syndrome 7 protein (289-393AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BBS7

Target: BBS7 (Bardet-Biedl Syndrome 7 (BBS7))

Alternative Name: BBS7 (BBS7 Products)

Synonyms: BBS7 antibody, bbs2l1 antibody, BBS2L1 antibody, id:ibd5048 antibody, zgc:153772 antibody, 8430406N16Rik antibody, Bardet-Biedl syndrome 7 antibody, bardet-biedl syndrome 7 antibody, Bardet-Biedl syndrome 7 L homeolog antibody, Bardet-Biedl syndrome 7 (human) antibody, BBS7 antibody, bbs7 antibody, MICPUN_100192 antibody, MICPUCDRAFT_16331 antibody, bbs7.L antibody, Bbs7 antibody

Background:

Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.

Aliases: Bardet Biedl syndrome 7 protein antibody, Bardet-Biedl syndrome 7 antibody, Bardet-Biedl syndrome 7 protein antibody, BBS2 like 1 antibody, BBS2 like protein 1 antibody, BBS2-like protein 1 antibody, BBS2L1 antibody, BBS7 antibody, BBS7_HUMAN antibody, FLJ10715 antibody

UniProt: Q8IWZ6

Pathways: Hedgehog Signaling