BBS5 antibody (AA 224-317) (Biotin)

Catalog No. ABIN7145243

Product Details anti-BBS5 Antibody (Biotin)

Target: BBS5 (Bardet-Biedl Syndrome 5 (BBS5))

Binding Specificity: AA 224-317

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BBS5 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Bardet-Biedl syndrome 5 protein (224-317AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BBS5

Target: BBS5 (Bardet-Biedl Syndrome 5 (BBS5))

Alternative Name: BBS5 (BBS5 Products)

Synonyms: zgc:56578 antibody, 1700049I01Rik antibody, 2700023J09Rik antibody, Bardet-Biedl syndrome 5 antibody, Bardet-Biedl syndrome 5 (human) antibody, bbs5 antibody, BBS5 antibody, Bbs5 antibody

Background:

Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.

Aliases: Bardet Biedl syndrome 5 protein antibody, Bardet-Biedl syndrome 5 protein antibody, BBS5 antibody, BBS5_HUMAN antibody

UniProt: Q8N3I7

Pathways: Hedgehog Signaling