BBS1 antibody (AA 217-417)

Catalog No. ABIN7145231

Product Details anti-BBS1 Antibody

Target: BBS1 (Bardet-Biedl Syndrome 1 (BBS1))

Binding Specificity: AA 217-417

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BBS1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Bardet-Biedl syndrome 1 protein (217-417AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BBS1

Target: BBS1 (Bardet-Biedl Syndrome 1 (BBS1))

Alternative Name: BBS1 (BBS1 Products)

Synonyms: im:7144669 antibody, bbs2l2 antibody, BBS1 antibody, DKFZp468B1612 antibody, BBS2L2 antibody, AI451249 antibody, D19Ertd609e antibody, Bardet-Biedl syndrome 1 antibody, bardet-biedl syndrome 1 antibody, Bardet-Biedl syndrome 1 (human) antibody, BBS1 antibody, bbs1 antibody, Bbs1 antibody

Background:

Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.

Aliases: AI451249 antibody, Bardet-Biedl syndrome 1 antibody, Bardet-Biedl syndrome 1 homolog antibody, Bardet-Biedl syndrome 1 protein antibody, BBS1 antibody, BBS1_HUMAN antibody, BBS2-like protein 2 antibody, BBS2L2 antibody, D19Ertd609e antibody

UniProt: Q8NFJ9

Pathways: Hedgehog Signaling