BIRC2 antibody (AA 1-300)

Catalog No. ABIN7145198

Product Details anti-BIRC2 Antibody

Target: BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))

Binding Specificity: AA 1-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIRC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Baculoviral IAP repeat-containing protein 2 protein (1-300AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BIRC2

Target: BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))

Alternative Name: BIRC2 (BIRC2 Products)

Synonyms: API1 antibody, HIAP2 antibody, Hiap-2 antibody, MIHB antibody, RNF48 antibody, c-IAP1 antibody, cIAP1 antibody, Api2 antibody, rIAP1 antibody, IAP1 antibody, ITA antibody, AW146227 antibody, Api1 antibody, Birc3 antibody, HIAP1 antibody, IAP2 antibody, MIAP1 antibody, MIAP2 antibody, MIHC antibody, cIAP2 antibody, mcIAP1 antibody, ciap-1 antibody, birc3 antibody, api1 antibody, birc2 antibody, c-iap1 antibody, ciap1 antibody, hiap-2 antibody, hiap2 antibody, mihb antibody, rnf48 antibody, baculoviral IAP repeat containing 2 antibody, baculoviral IAP repeat-containing 2 antibody, baculoviral IAP repeat containing 2 L homeolog antibody, BIRC2 antibody, Birc2 antibody, birc2 antibody, birc2.L antibody

Background:

Background: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.

Aliases: API 1 antibody, API1 antibody, Apoptosis inhibitor 1 antibody, Baculoviral IAP repeat containing 2 antibody, Baculoviral IAP repeat containing protein 2 antibody, Baculoviral IAP repeat-containing protein 2 antibody, BIRC 2 antibody, BIRC2 antibody, BIRC2_HUMAN antibody, C IAP1 antibody, C-IAP1 antibody, Cellular inhibitor of apoptosis 1 antibody, cellular inhibitor of apoptosis protein 1 antibody, cIAP 1 antibody, cIAP1 antibody, HIAP 2 antibody, HIAP-2 antibody, HIAP2 antibody, IAP 2 antibody, IAP homolog B antibody, IAP-2 antibody, IAP2 antibody, Inhibitor of apoptosis protein 2 antibody, MIHB antibody, NFR2 TRAF signalling complex protein antibody, RING finger protein 48 antibody, RNF 48 antibody, RNF48 antibody, TNFR2 TRAF signaling complex protein 2 antibody, TNFR2-TRAF-signaling complex protein 2 antibody

UniProt: Q13490

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades