NAIP antibody (AA 147-242)

Catalog No. ABIN7145194

Product Details anti-NAIP Antibody

Target: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Binding Specificity: AA 147-242

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAIP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Baculoviral IAP repeat-containing protein 1 protein (147-242AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NAIP

Target: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Alternative Name: NAIP (NAIP Products)

Synonyms: BIRC1 antibody, NLRB1 antibody, psiNAIP antibody, AV364616 antibody, Birc1a antibody, D13Lsd1 antibody, Naip antibody, Naip-rs1 antibody, NLR family apoptosis inhibitory protein antibody, NLR family, apoptosis inhibitory protein 1 antibody, NAIP antibody, Naip1 antibody

Background:

Background: \\\"Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at \\\'Asp-315\\\' and decreasing the rate of auto proteolysis at \\\'Asp-330\\\'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy. Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.\\\"

Aliases: Baculoviral IAP repeat containing 1 antibody, Baculoviral IAP repeat-containing protein 1 antibody, BIRC 1 antibody, BIRC1 antibody, BIRC1_HUMAN antibody, Birc1a antibody, FLJ42520 antibody, NAIP antibody, Naip1 antibody, Neuronal apoptosis inhibitory protein antibody, NLR family apoptosis inhibitory protein antibody, NLR family BIR domain containing 1 antibody, NLRB 1 antibody, NLRB1 antibody, Nucleotide binding oligomerization domain leucine rich repeat and BIR domain containing 1 antibody, Psi neuronal apoptosis inhibitory protein antibody, psiNAIP antibody, Similar to occludin antibody

UniProt: Q13075

Pathways: Apoptosis, Inflammasome