CD79a antibody (AA 70-142)

Catalog No. ABIN7145141

Product Details anti-CD79a Antibody

Target: CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))

Binding Specificity: AA 70-142

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD79a antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human B-cell antigen receptor complex-associated protein alpha chain protein (70-142AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CD79a

Target: CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))

Alternative Name: CD79A (CD79A Products)

Synonyms: CD79A antibody, Ig-alpha antibody, Iga antibody, Igalpha antibody, Ly-54 antibody, Ly54 antibody, mb-1 antibody, IGA antibody, MB-1 antibody, IG-alpha antibody, CD79a molecule antibody, CD79A antigen (immunoglobulin-associated alpha) antibody, Cd79a molecule-like antibody, CD79A antibody, Cd79a antibody, Cd79al antibody

Background:

Background: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

Aliases: B lymphocyte-specific MB1 protein antibody, B-cell antigen receptor complex-associated protein alpha chain antibody, CD 79a antibody, CD79a antibody, CD79a antigen (immunoglobulin-associated alpha) antibody, CD79A antigen antibody, CD79a molecule, immunoglobulin-associated alpha antibody, CD79A_HUMAN antibody, Ig alpha antibody, Ig-alpha antibody, IGA antibody, IgM-alpha antibody, Immunoglobulin-associated alpha antibody, Ly54 antibody, MB-1 membrane glycoprotein antibody, MB1 antibody, Membrane-bound immunoglobulin-associated protein antibody, Surface IgM-associated protein antibody

UniProt: P11912

Pathways: BCR Signaling