Aurora Kinase C antibody (AA 12-143)

Catalog No. ABIN7145083

Product Details anti-Aurora Kinase C Antibody

Target: Aurora Kinase C (AURKC)

Binding Specificity: AA 12-143

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aurora Kinase C antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Aurora kinase C protein (12-143AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Aurora Kinase C

Target: Aurora Kinase C (AURKC)

Alternative Name: AURKC (AURKC Products)

Synonyms: AURKC antibody, AIE2 antibody, AIK3 antibody, ARK3 antibody, AurC antibody, SPGF5 antibody, STK13 antibody, aurora-C antibody, AIE1 antibody, ARK-3 antibody, IAK3 antibody, Stk13 antibody, aurora kinase C antibody, AURKC antibody, Aurkc antibody

Background:

Background: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at \\\'Ser-10\\\' and \\\'Ser-28\\\'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at \\\'Ser-228\\\'.

Aliases: AURKC antibody, AIE 2 antibody, Aie1 antibody, AIE2 antibody, AIK 3 antibody, AIK3 antibody, ARK 3 antibody, ARK-3 antibody, ARK3 antibody, Aur C antibody, AurC antibody, Aurkc antibody, AURKC_HUMAN antibody, aurora 3 antibody, Aurora C antibody, Aurora kinase C antibody, aurora related kinase 3 antibody, Aurora-related kinase 3 antibody, Aurora/Ipl1 related kinase 3 antibody, Aurora/Ipl1-related kinase 3 antibody, Aurora/Ipl1/Eg2 protein 2 antibody, EC 2.7.11.1 antibody, Serine threonine protein kinase 13 antibody, serine/threonine kinase 13 (aurora/IPL1 like) antibody, serine/threonine protein kinase aurora C antibody, Serine/threonine-protein kinase 13 antibody, Serine/threonine-protein kinase aurora-C antibody, SPGF5 antibody, STK13 antibody

UniProt: Q9UQB9

Pathways: Cell Division Cycle, Maintenance of Protein Location