ARID1A antibody (AA 655-816)

Catalog No. ABIN7144775

Product Details anti-ARID1A Antibody

Target: ARID1A (AT Rich Interactive Domain 1A (SWI-Like) (ARID1A))

Binding Specificity: AA 655-816

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARID1A antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human AT-rich interactive domain-containing protein 1A protein (655-816AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ARID1A

Target: ARID1A (AT Rich Interactive Domain 1A (SWI-Like) (ARID1A))

Alternative Name: ARID1A (ARID1A Products)

Background:

Background: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Aliases: actin-dependent regulator of chromatin subfamily F member 1 antibody, ARI1A_HUMAN antibody, ARID domain containing protein 1A antibody, ARID domain-containing protein 1A antibody, ARID1A antibody, AT rich interactive domain 1A (SWI like) antibody, AT rich interactive domain 1A antibody, AT rich interactive domain containing protein 1A antibody, AT-rich interactive domain-containing protein 1A antibody, B120 antibody, BAF250 antibody, BAF250A antibody, BM029 antibody, brain protein 120 antibody, BRG1 associated factor 250 antibody, BRG1 associated factor 250a antibody, BRG1-associated factor 250 antibody, BRG1-associated factor 250a antibody, C1ORF4 antibody, chromatin remodeling factor p250 antibody, chromosome 1 open reading frame 4 antibody, ELD antibody, hELD antibody, hOSA1 antibody, matrix-associated antibody, MRD14 antibody, Osa homolog 1 antibody, OSA1 antibody, OSA1 nuclear protein antibody, P270 antibody, SMARCF1 antibody, SWI like protein antibody, SWI SNF complex protein p270 antibody, SWI-like protein antibody, SWI/SNF complex protein p270 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1 antibody, SWI/SNF-related antibody

UniProt: O14497

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Tube Formation