ALOX12 antibody (AA 508-658) (Biotin)

Catalog No. ABIN7144529

Product Details anti-ALOX12 Antibody (Biotin)

Target: ALOX12 (Arachidonate 12-Lipoxygenase (ALOX12))

Binding Specificity: AA 508-658

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALOX12 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Arachidonate 12-lipoxygenase, 12S-type protein (508-658AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ALOX12

Target: ALOX12 (Arachidonate 12-Lipoxygenase (ALOX12))

Alternative Name: ALOX12 (ALOX12 Products)

Synonyms: 15-LOX-1 antibody, 15LOX-1 antibody, 12-LOX antibody, 12S-LOX antibody, LOG12 antibody, ALOX12 antibody, ALOX15 antibody, 9930022G08Rik antibody, Alox12p antibody, P-12LO antibody, 12-LO antibody, zgc:64120 antibody, wu:fb72a11 antibody, arachidonate 15-lipoxygenase antibody, arachidonate 12-lipoxygenase, 12S type antibody, arachidonate 12-lipoxygenase antibody, arachidonate 12-lipoxygenase, 12S-type antibody, ALOX15 antibody, ALOX12 antibody, Alox12 antibody, alox12 antibody, LOC100072916 antibody

Background:

Background: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.

Aliases: 12 LOX antibody, 12(S) lipoxygenase antibody, 12-lipoxygenase antibody, 12LO antibody, 12S LOX antibody, 12S-lipoxygenase antibody, 12S-LOX antibody, 12S-type antibody, Alox12 antibody, Arachidonate 12 lipoxygenase antibody, Arachidonate 12 lipoxygenase, 12S type antibody, Arachidonate 12-lipoxygenase antibody, Arachidonate 12-oxidoreductase antibody, Lipoxin synthase 12-LO antibody, LOG12 antibody, LOX12_HUMAN antibody, P-12LO antibody, Platelet 12-LOX antibody, Platelet type lipoxygenase 12 antibody, platelet-type 12-lipoxygenase antibody, Platelet-type lipoxygenase 12 antibody

UniProt: P18054

Pathways: Positive Regulation of Endopeptidase Activity