ALOX12B antibody (AA 484-663) (Biotin)
-
- Target See all ALOX12B Antibodies
- ALOX12B (Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B))
-
Binding Specificity
- AA 484-663
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This ALOX12B antibody is conjugated to Biotin
-
Application
- ELISA
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Arachidonate 12-lipoxygenase, 12R-type protein (484-663AA)
- Isotype
- IgG
- Top Product
- Discover our top product ALOX12B Primary Antibody
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- Target
- ALOX12B (Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B))
- Alternative Name
- ALOX12B (ALOX12B Products)
- Synonyms
- ALOX12B antibody, MGC107915 antibody, MGC85124 antibody, 12R-LOX antibody, ARCI2 antibody, Aloxe2 antibody, e-LOX2 antibody, arachidonate 12-lipoxygenase, 12R type antibody, arachidonate 12-lipoxygenase, 12R type S homeolog antibody, ALOX12B antibody, alox12b antibody, alox12b.S antibody, Alox12b antibody
- Background
-
Background: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.
Aliases: ALOX12B antibody, Arachidonate 12-lipoxygenase antibody, 12R-type antibody, 12R-LOX antibody, 12R-lipoxygenase antibody, EC 1.13.11.- antibody, Epidermis-type lipoxygenase 12 antibody
- UniProt
- O75342
- Pathways
- Cell-Cell Junction Organization
-