AAK1 antibody (AA 274-465)
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- Target See all AAK1 Antibodies
- AAK1 (AP2 associated kinase 1 (AAK1))
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Binding Specificity
- AA 274-465
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This AAK1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human, Mouse
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human AP2-associated protein kinase 1 protein (274-465AA)
- Isotype
- IgG
- Top Product
- Discover our top product AAK1 Primary Antibody
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- Application Notes
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- AAK1 (AP2 associated kinase 1 (AAK1))
- Alternative Name
- AAK1 (AAK1 Products)
- Synonyms
- 5530400K14Rik antibody, 9630042K20 antibody, AU067724 antibody, AU067726 antibody, BC028270 antibody, C79663 antibody, D6Ertd245e antibody, R75501 antibody, mKIAA1048 antibody, RGD1563580 antibody, aak1 antibody, si:dkey-261l11.5 antibody, AP2 associated kinase 1 antibody, uncharacterized protein FLJ45252 antibody, AP2 associated kinase 1b antibody, AAK1 antibody, Aak1 antibody, LOC100512341 antibody, aak1b antibody
- Background
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Background: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
Aliases: AAK 1 antibody, Aak1 antibody, AAK1_HUMAN antibody, Adaptor associated kinase 1 antibody, Adaptor-associated kinase 1 antibody, AP2 associated kinase 1 antibody, AP2 associated protein kinase 1 antibody, AP2-associated protein kinase 1 antibody, DKFZp686F03202 antibody, DKFZp686K16132 antibody, FLJ23712 antibody, FLJ25931 antibody, FLJ31060 antibody, FLJ42882 antibody, FLJ45252 antibody, KIAA1048 antibody, MGC138170 antibody, MGC164568 antibody, MGC164570 antibody
- UniProt
- Q2M2I8
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