TAP2 antibody (AA 473-615) (FITC)
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- Target See all TAP2 Antibodies
- TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))
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Binding Specificity
- AA 473-615
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TAP2 antibody is conjugated to FITC
- Application
- Please inquire
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Antigen peptide transporter 2 protein (473-615AA)
- Isotype
- IgG
- Top Product
- Discover our top product TAP2 Primary Antibody
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))
- Alternative Name
- TAP2 (TAP2 Products)
- Synonyms
- ABC18 antibody, ABCB3 antibody, APT2 antibody, D6S217E antibody, PSF-2 antibody, PSF2 antibody, RING11 antibody, AI462429 antibody, Abcb3 antibody, Ham-2 antibody, Ham2 antibody, MTP2 antibody, Tap-2 antibody, Y1 antibody, jas antibody, Cim antibody, transporter 2, ATP binding cassette subfamily B member antibody, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) antibody, TAP2 antibody, Tap2 antibody
- Background
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Background: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Aliases: ABC transporter, MHC 2 antibody, ABC18 antibody, ABCB3 antibody, Antigen peptide transporter 2 antibody, APT2 antibody, ATP binding cassette, sub family B (MDR/TAP), member 3 antibody, ATP-binding cassette sub-family B member 3 antibody, D6S217E antibody, Peptide supply factor 2 antibody, Peptide transporter involved in antigen processing 2 antibody, Peptide transporter PSF2 antibody, Peptide transporter TAP2 antibody, PSF 2 antibody, PSF-2 antibody, PSF2 antibody, Really interesting new gene 11 protein antibody, RING 11 antibody, RING11 antibody, TAP 2 antibody, Tap2 antibody, TAP2_HUMAN antibody, Transporter 2 ATP binding cassette sub family B antibody, Transporter 2, ABC (ATP binding cassette antibody, Transporter 2, ATP binding cassette, sub family B (MDR/TAP) antibody
- UniProt
- Q03519
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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