Chromosome 6 Open Reading Frame 134 (C6orf134) (AA 194-238) antibody

Catalog No. ABIN7143948

Product Details

Target: Chromosome 6 Open Reading Frame 134 (C6orf134)

Binding Specificity: AA 194-238

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Alpha-tubulin N-acetyltransferase 1 protein (194-238AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:200-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: Chromosome 6 Open Reading Frame 134 (C6orf134)

Alternative Name: ATAT1 (C6orf134 Products)

Synonyms: C6orf134 antibody, MEC17 antibody, Nbla00487 antibody, TAT antibody, mec17 antibody, wu:fj19c03 antibody, zgc:65893 antibody, zgc:77443 antibody, Alpha-TAT antibody, c6orf134 antibody, C23H6orf134 antibody, 0610011P08Rik antibody, 2610008K08Rik antibody, 2610110G12Rik antibody, 3110080J08Rik antibody, Mec17 antibody, RGD1303066 antibody, C7H6ORF134 antibody, C4H6orf134 antibody, alpha tubulin acetyltransferase 1 antibody, alpha tubulin acetyltransferase 1 S homeolog antibody, ATAT1 antibody, atat1 antibody, atat1.S antibody, Atat1 antibody

Background:

Background: Specifically acetylates \'Lys-40\' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics, this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.

Aliases: Acetyltransferase mec 17 homolog antibody, Acetyltransferase mec-17 homolog antibody, Alpha TAT antibody, Alpha tubulin acetyltransferase 1 antibody, Alpha tubulin N acetyltransferase antibody, Alpha-TAT antibody, Alpha-tubulin N-acetyltransferase antibody, ATAT_HUMAN antibody, ATAT1 antibody, Chromosome 6 open reading frame 134 antibody, Hypothetical protein LOC79969 antibody, MEC17 antibody, Nbla00487 antibody, TAT antibody

UniProt: Q5SQI0