ALKBH3 antibody (AA 1-170)

Catalog No. ABIN7143886

Product Details anti-ALKBH3 Antibody

Target: ALKBH3 (AlkB, Alkylation Repair Homolog 3 (ALKBH3))

Binding Specificity: AA 1-170

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALKBH3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 protein (1-170AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ALKBH3

Target: ALKBH3 (AlkB, Alkylation Repair Homolog 3 (ALKBH3))

Alternative Name: ALKBH3 (ALKBH3 Products)

Synonyms: ABH3 antibody, DEPC-1 antibody, DEPC1 antibody, PCA1 antibody, 1700108H04Rik antibody, 1810020C19Rik antibody, Abh3 antibody, mABH3 antibody, alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase L homeolog antibody, alkB homolog 3, alpha-ketoglutaratedependent dioxygenase antibody, alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase antibody, alkbh3.L antibody, ALKBH3 antibody, Alkbh3 antibody

Background:

Background: Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.

Aliases: 1700108H04Rik antibody, 1810020C19Rik antibody, ABH3 antibody, AlkB homolog 3 antibody, alkB, alkylation repair homolog 3 (E. coli) antibody, ALKB3_HUMAN antibody, ALKBH3 antibody, Alkylated DNA repair protein alkB homolog 3 antibody, alkylation repair homolog 3 antibody, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 antibody, DEPC 1 antibody, DEPC-1 antibody, DEPC1 antibody, EC 1.14.11. antibody, FLJ43614 antibody, mABH3 antibody, MGC118790 antibody, MGC118792 antibody, MGC118793 antibody, MGC134125 antibody, PCA1 antibody, Prostate cancer antigen 1 antibody, Prostate cancer antigen-1 antibody, RP23-375N21.4 antibody

UniProt: Q96Q83

Pathways: DNA Damage Repair