A2ML1 antibody (AA 625-751)

Catalog No. ABIN7143798

Product Details anti-A2ML1 Antibody

Target: A2ML1 (alpha-2-Macroglobulin-Like 1 (A2ML1))

Binding Specificity: AA 625-751

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This A2ML1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Alpha-2-macroglobulin-like protein 1 protein (625-751AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for A2ML1

Target: A2ML1 (alpha-2-Macroglobulin-Like 1 (A2ML1))

Alternative Name: A2ML1 (A2ML1 Products)

Synonyms: CPAMD9 antibody, alpha-2-macroglobulin like 1 antibody, A2ML1 antibody

Background:

Background: Is able to inhibit all four classes of proteinases by a unique \\\'trapping\\\' mechanism. This protein has a peptide stretch, called the \\\'bait region\\\' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.

Aliases: A2ML1 antibody, CPAMD9Alpha-2-macroglobulin-like protein 1 antibody, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9 antibody

UniProt: A8K2U0