ALKBH8 antibody (AA 1-230)

Catalog No. ABIN7143718

Product Details anti-ALKBH8 Antibody

Target: ALKBH8 (AlkB, Alkylation Repair Homolog 8 (ALKBH8))

Binding Specificity: AA 1-230

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALKBH8 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Alkylated DNA repair protein alkB homolog 8 protein (1-230AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ALKBH8

Target: ALKBH8 (AlkB, Alkylation Repair Homolog 8 (ALKBH8))

Alternative Name: ALKBH8 (ALKBH8 Products)

Synonyms: ABH8 antibody, 4930562C03Rik antibody, 8030431D03Rik antibody, 9430088N01Rik antibody, Abh8 antibody, alkB homolog 8, tRNA methyltransferase antibody, ALKBH8 antibody, Alkbh8 antibody

Background:

Background: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine, has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).

Aliases: 4930562C03Rik antibody, 8030431D03Rik antibody, 9430088N01Rik antibody, ABH8 antibody, alkB alkylation repair homolog 8 (E. coli) antibody, alkB alkylation repair homolog 8 antibody, AlkB homologue 8 antibody, ALKB8_HUMAN antibody, ALKBH8 antibody, Alkylated DNA repair protein alkB homolog 8 antibody, FLJ38204 antibody, MGC10235 antibody, OTTHUMP00000211286 antibody, OTTHUMP00000211287 antibody, Probable alpha-ketoglutarate-dependent dioxygenase ABH8 antibody, RGD1304687 antibody, S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8 antibody, tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8 antibody

UniProt: Q96BT7